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There have also been changes over time in the type of lung cancer smokers develop – a decline in squamous cell carcinomas but a dramatic increase in adenocarcinomas.Both of these shifts may be due to changes in cigarette design and composition, in how tobacco leaves are cured, and in how deeply smokers inhale cigarette smoke and the toxicants it contains (1, 8).Quitting smoking reduces the risk of cancer and many other diseases, such as heart disease and COPD, caused by smoking. Smokers who quit before age 40 reduce their chance of dying prematurely from smoking-related diseases by about 90%, and those who quit by age 45-54 reduce their chance of dying prematurely by about two-thirds (6). National Health Interview Survey also show that those who quit between the ages of 25 and 34 years live about 10 years longer; those who quit between ages 35 and 44 live about 9 years longer; those who quit between ages 45 and 54 live about 6 years longer; and those who quit between ages 55 and 64 live about 4 years longer (6).

Of the more than 7,000 chemicals in tobacco smoke, at least 250 are known to be harmful, including hydrogen cyanide, carbon monoxide, and ammonia (1, 2, 5).

Among the 250 known harmful chemicals in tobacco smoke, at least 69 can cause cancer.

Smoking also causes heart disease, stroke, aortic aneurysm (a balloon-like bulge in an artery in the chest), chronic obstructive pulmonary disease (COPD) (chronic bronchitis and emphysema), diabetes, osteoporosis, rheumatoid arthritis, age-related macular degeneration, and cataracts, and worsens asthma symptoms in adults.

Smokers are at higher risk of developing pneumonia, tuberculosis, and other airway infections (1–3).

Secondhand smoke (also called environmental tobacco smoke, involuntary smoking, and passive smoking) is the combination of “sidestream” smoke (the smoke given off by a burning tobacco product) and “mainstream” smoke (the smoke exhaled by a smoker) (4, 5, 10, 11). In the United States, exposure to secondhand smoke is estimated to cause about 34,000 deaths from heart disease each year (1).

Exposure to secondhand smoke also increases the risk of stroke by 20 to 30% (1).Secondhand smoke exposure can also increase the frequency and severity of asthma symptoms among children who have asthma.Being exposed to secondhand smoke slows the growth of children’s lungs and can cause them to cough, wheeze, and feel breathless (2, 4). Nicotine is the drug primarily responsible for a person’s addiction to tobacco products, including cigarettes.Smoking harms nearly every bodily organ and organ system in the body and diminishes a person’s overall health.Smoking causes cancers of the lung, esophagus, larynx, mouth, throat, kidney, bladder, liver, pancreas, stomach, cervix, colon, and rectum, as well as acute myeloid leukemia (1–3).Pregnant women exposed to secondhand smoke are at increased risk of having a baby with a small reduction in birth weight (1).Children exposed to secondhand smoke are at an increased risk of SIDS, ear infections, colds, pneumonia, and bronchitis.Although it is never too late to benefit from quitting, the benefit is greatest among those who quit at a younger age (3).The risk of premature death and the chances of developing and dying from a smoking-related cancer depend on many factors, including the number of years a person has smoked, the number of cigarettes smoked per day, and the age at which the person began smoking.A woman who smokes during or after pregnancy increases her infant’s risk of death from Sudden Infant Death Syndrome (SIDS) (2, 3). Inhaling secondhand smoke causes lung cancer in nonsmoking adults (1, 2, 4). Surgeon General estimates that living with a smoker increases a nonsmoker’s chances of developing lung cancer by 20 to 30% (4).Men who smoke are at greater risk of erectile dysfunction (1, 9). Approximately 7,300 lung cancer deaths occur each year among adult nonsmokers in the United States as a result of exposure to secondhand smoke (1). Secondhand smoke causes disease and premature death in nonsmoking adults and children (2, 4).

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