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Sedating antihistamines and alcohol

Acrivastine 4 and 8 mg,given with and without alcohol, was found in a study to behave like terfenadine (which interacts minimally or not at all) (See reference number 4).Other studies have shown that astemizole 10 to 30mg daily,(See reference number 5-7)desloratadine,(See reference number 8)ebastine 20 mg,(See reference number 9)fexofenadine 120 to 240 mg,(See reference number 10,11)levocabastine 2 nasal puffs of 0.5 mg/m L,(See reference number 12)loratadine 10 to 20 mg(See reference number 2,13) and mizolastine 10 mg(See reference number 14)do not interact with alcohol.Another study had similar findings (See reference number 2).

Sedating antihistamines cause drowsiness and may therefore affect your ability to drive or operate machinery safely.

If you continue to drink alcohol, you may potentially decrease the risk of harm by not drinking 2-3 hours before and after taking a drug —-For high blood pressure: clonidine, enalapril, guanadrel, guanethidine, hydralazine, hydrochlorothiazide, lisinopril, losartan, methyldopa, nitroglycerine, prazosin, propranolol, reserpine, terazosin, verapamil The Microsomal Enzyme Oxidizing System (MEOS) in the liver breaks down both alcohol and certain drugs.

During and up to several hours after drinking, MEOS is busy by breaking down alcohol, which slows down the breakdown of drugs taken in this time and thus increases and prolongs their effects and side effects In chronic alcoholics who are sober, the activity of another enzyme system CYP2E1 (which breaks down both alcohol and certain drugs) is increased, which decreases and shortens the effects of certain drugs may cause flushing and nausea, because a substance coprine from a mushroom inhibits the enzyme ALDH2 that converts acetaldehyde (a breakdown product of ethanol) to acetate, what results in buildup of acetaldehyde in the blood .

Also beware of a 'hangover' effect in the morning if the tablets are taken too late at night.

All medicines have possible side-effects, though you may not necessarily experience any.

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